- What is filtration in cell membrane?
- What is filtration and diffusion?
- What is filtration in anatomy and physiology?
- What is filtration transport?
- What are the 2 main types of active transport?
- What are the two main components of the cell membrane?
- What is a membrane transport system?
- How are drugs transported across cell membranes?
- What are the factors affecting cell membrane transport?
- Which type of drug Cannot enter the cell membrane?
- How drugs are transported in the blood?
- Which organs are affected by ADR?
- How Drug distribution is affected by blood flow?
- How are drugs distributed?
- What are the three types of drug interactions?
- What are the factors that affect drug distribution?
- What are the 4 pharmacokinetic principles?
What is filtration in cell membrane?
Filtration is another passive process of moving material through a cell membrane. While diffusion and osmosis rely on concentration gradients, filtration uses a pressure gradient. Molecules will move from an area of higher pressure to an area of lower pressure. Filtration is non-specific.
What is filtration and diffusion?
Diffusion is the movement of one specific molecule from a high concentration area to a low concentration one. Filtration is the movement of a fluid (mixture of several molecules) from a region of high pressure to a region of a low pressure.
What is filtration in anatomy and physiology?
Filtration involves the transfer of soluble components, such as water and waste, from the blood into the glomerulus. Reabsorption involves the absorption of molecules, ions, and water that are necessary for the body to maintain homeostasis from the glomerular filtrate back into the blood.
What is filtration transport?
Filtration. Filtration is another type of passive transport, and refers to the movement of water and other molecules across the cell membrane due to hydrostatic pressure generated by the cardiovascular system.
What are the 2 main types of active transport?
There are two main types of active transport:
- Primary (direct) active transport – Involves the direct use of metabolic energy (e.g. ATP hydrolysis) to mediate transport.
- Secondary (indirect) active transport – Involves coupling the molecule with another moving along an electrochemical gradient.
What are the two main components of the cell membrane?
The principal components of the plasma membrane are lipids (phospholipids and cholesterol), proteins, and carbohydrate groups that are attached to some of the lipids and proteins. A phospholipid is a lipid made of glycerol, two fatty acid tails, and a phosphate-linked head group.
What is a membrane transport system?
From Wikipedia, the free encyclopedia. In cellular biology, membrane transport refers to the collection of mechanisms that regulate the passage of solutes such as ions and small molecules through biological membranes, which are lipid bilayers that contain proteins embedded in them.
How are drugs transported across cell membranes?
Drugs diffuse across a cell membrane from a region of high concentration (eg, gastrointestinal fluids) to one of low concentration (eg, blood). Diffusion rate is directly proportional to the gradient but also depends on the molecule’s lipid solubility, size, degree of ionization, and the area of absorptive surface.
What are the factors affecting cell membrane transport?
Many factors can affect the rate of diffusion, including, but not limited to, concentration gradient, size of the particles that are diffusing, and temperature of the system. In living systems, diffusion of substances in and out of cells is mediated by the plasma membrane.
Which type of drug Cannot enter the cell membrane?
Very large drug molecules—such as proteins and polysaccharides used as plasma expanders—cannot cross the basal membranes of the capillaries to reach the interstitial space and will remain confined to the circulation; they will therefore occur in the blood plasma at high concentrations.
How drugs are transported in the blood?
Drug is transported by convection in the bloodstream through the systemic veins, the heart, the lungs and the systemic arteries to peripheral microvessels. Owing to rapid mixing of solutes in the blood, all parts of the circulatory system are exposed to the drug.
Which organs are affected by ADR?
Idiosyncratic adverse drug reactions can affect a number of different organs, including the liver, skin, kidney, heart and muscle, and, with some drugs, more generalized hypersensitivity reactions can occur.
How Drug distribution is affected by blood flow?
After a drug enters the systemic circulation, it is distributed to the body’s tissues. Distribution is generally uneven because of differences in blood perfusion, tissue binding (eg, because of lipid content), regional pH, and permeability of cell membranes.
How are drugs distributed?
After a drug is absorbed into the bloodstream (see Drug Absorption), it rapidly circulates through the body. The average circulation time of blood is 1 minute. As the blood recirculates, the drug moves from the bloodstream into the body’s tissues. Once absorbed, most drugs do not spread evenly throughout the body.
What are the three types of drug interactions?
Drug interactions can be categorised into 3 groups:
- Interactions of drugs with other drugs (drug-drug interactions),
- Drugs with food (drug-food interactions)
- Drug with disease condition (drug-disease interactions).
What are the factors that affect drug distribution?
Drug distribution is affected by many factors, including plasma or tissue protein binding, body weight, body composition, and body fluid spaces (8). Of these, total body weight, muscle mass, and fat composition are the major determinants of drug distribution, and women may differ from men in both of these factors.
What are the 4 pharmacokinetic principles?
There are four main components of pharmacokinetics: liberation, absorption, distribution, metabolism and excretion (LADME). These are used to explain the various characteristics of different drugs in the body.